The next two weeks in General Hospital promise to shake Port Charles to its core. From devastating goodbyes to shocking returns, alliances will fracture, long-buried secrets will rise to the surface, and every corner of

the city will feel the ripple effect of Monica Quartermaine’s heartbreaking death. The weeks of September 15–19 and September 22–26, 2025, will not just deliver ordinary soap drama—

they will redefine legacies, test loyalties, and unleash new dangers that no one in Port Charles can escape.

Monica Quartermaine’s Death Sends Shockwaves Through Port Charles

The beating heart of the Quartermaine family, Monica Quartermaine, has passed away. The loss is first whispered in hushed corridors of General Hospital, a text here, a hesitant glance there, before the truth spreads like wildfire: Monica is gone.

Jason Morgan is among the first to confront the devastating confirmation. For a man who thrives on order and control, the news shatters him in a thousand ways. His grief doesn’t stay private—Jason carries it across Port Charles like a dark storm, knocking on doors, delivering the news, and forcing everyone he encounters to face the truth. His silent, grief-stricken presence becomes its own announcement.

The Quartermaine estate, steeped in history, portraits, and grudges, now turns into the epicenter of heartbreak. Tracy Quartermaine, who has so often treated grief as a tool for strategy, finds herself stripped bare. For once, she drops her armor and becomes Jason’s unexpected support system. Their shared sorrow for Monica begins to redraw family lines, binding them in ways neither expected.

Drew Kane’s Painful Absence

Far from the Quartermaine mansion, Drew Kane receives the news from Elizabeth Baldwin. Drew, long hardened by ruthless choices and heavy burdens, is pierced by this loss in a way he cannot mask. Yet, due to a devastating injury, he cannot attend Monica’s funeral. Instead, he makes a symbolic choice—sending Scout to represent him. Danny Morgan steps in to escort Scout, forging a tender moment of continuity amid the sorrow.

Though absent in body, Drew’s grief looms over the funeral. His decision reminds Port Charles that even the strongest walls crack under the weight of family loss.

A Funeral Filled With Revelations

Monica’s funeral becomes more than a farewell—it is a seismic shift for Port Charles. In a stunning twist, Erica Slezak appears as Monica’s sister, arriving with the emotional gravity of unfinished business. As she reads Monica’s will, the room falls silent. Each clause carries Monica’s voice beyond the grave—gifts of reconciliation, stinging truths, and instructions that will shape her family’s future.

The will isn’t just a legal document—it’s a prophecy. Some will leave the service comforted, while others will be haunted. Old grudges reignite, and fragile alliances begin to crack under the weight of Monica’s final wishes.

Christina’s Secret Plans and Cody’s Heart

Elsewhere, Christina Corinthos Davis shifts her role in Port Charles’s ever-turbulent drama. Watching Cody Bell struggle with his feelings for Molly, Christina becomes the unlikely instigator of courage, urging him to seize the chance at love. Yet, her motives are not entirely pure. Behind her encouragement lies a darker, simmering plot against Ava Jerome.

Christina, entangled with Alexis and Ava in a dangerous secret, knows that timing is everything. While she pushes Cody toward Molly, her true focus remains on positioning her own scheme, carefully waiting for the perfect moment to strike. Every move she makes on Cody’s behalf doubles as a calculated step in her larger plan.

Emma and Gio’s Dangerous Mission

Meanwhile, Emma Scorpio-Drake and Gio Polieri find themselves in a crisis that could alter the balance of power in Port Charles. A shipment of scientific samples intended for Professor Henry Dalton crashes, scattering dangerous vials across asphalt. The spill sets off alarms—these materials cannot fall into the wrong hands.

Gio turns to Sonny Corinthos, and together they orchestrate a perilous recovery mission. Emma becomes the one tasked with retrieving the fragile samples, slipping into shadows while Sonny provides the muscle and protection. What Emma carries is more than broken glass—it’s a discovery that could reshape the future of Port Charles, depending on who ends up holding it.

Britt and Liesl’s Explosive Confrontation

As if grief weren’t enough, Nina Reeves finds herself stuck in the middle of another emotional battlefield. Britt Westbourne has returned, shocking everyone, but her staged disappearance leaves her mother, Liesl Obrecht, livid. Liesl’s fury is volcanic—not at Britt’s survival, but at her secrecy. Why did Britt vanish? What was she hiding?

Nina tries desperately to bridge the divide, but mother and daughter’s bond teeters on collapse. Britt’s silence becomes its own form of rebellion, while Liesl’s anger sharpens into accusations. This conflict isn’t just personal—it hints that Britt’s disappearance ties into darker, more dangerous forces at work in Port Charles.

Drew Framed, Anna’s Investigation, and Willow’s Loyalty

Drew’s troubles don’t end with grief. Brick, operating under manipulative orders, delivers false evidence framing Drew for bribery and even murder. Anna Devane, ever the sharp investigator, begins to suspect a much deeper conspiracy. Her instincts point toward a ghost from the past—Caesar Faison, a man believed dead but perhaps still pulling strings from the shadows.

Anna’s interrogation of Drew is clinical but searching, while Willow Tate fiercely leaps to Drew’s defense. She refuses to let his past be weaponized against him, clashing with Anna in a heated showdown. Their confrontation escalates until it explodes with a shocking slap—an unforgettable moment that fractures already delicate alliances.

Nathan West Returns From the Dead

In a twist no one saw coming, Nathan West is discovered alive after a devastating truck crash tied to the scattered vials. His injuries are severe, but his survival raises even bigger questions. Why is he alive? Where has he been all this time?

Lulu Spencer, stunned by the sight of him, rushes to his side. Her instinct to save him is immediate, but her heart races with questions. His return, alongside Britt’s, suggests something larger is at play—a conspiracy that spans far deeper than anyone realizes. Nathan’s reappearance could be the domino that tips Port Charles into an entirely new war.

A City Transformed

As Monica is laid to rest, Port Charles is left forever changed. Jason walks through the city carrying both grief and suspicion. Tracy, for once, allows her vulnerability to shine through. Drew wrestles with false charges and the fear that his loved ones may be caught in the crossfire. Christina balances love advice with secret plotting. Emma risks her life for a dangerous mission. Britt and Liesl’s fractured bond hints at darker truths. Anna hunts shadows that may prove the dead don’t always stay buried. And Lulu must face the reality that Nathan’s survival could tear open wounds that never healed.

In the next two weeks, General Hospital will not just mourn the loss of Monica Quartermaine—it will unravel a tapestry of secrets, betrayals, and impossible choices. Her death is the catalyst for a new era in Port Charles, and the reverberations will be felt for months to come.